Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing structural flexibility at or near the active sites.Inevitably, this feat seems to be accompanied by lower thermal stability.These characteristics have made cold-active enzymes into attractive targets for the industrial applications, since they could reduce the energy cost in the reaction, attenuate side-reactions, and My Mom Dad Is Well Trained Funny Cartoon Dog Gift For Dog Lover Personalized Shirt simply be inactivated.
In addition, the increased structural flexibility could result in broad substrate specificity for various non-native substrates, which is called substrate promiscuity.In this perspective, we deal with a less addressed aspect of cold-active enzymes, substrate promiscuity, which has enormous potential for semi-synthesis or enzymatic animed blue lotion topical spray modification of fine chemicals and drugs.Further structural and directed-evolutional studies on substrate promiscuity of cold-active enzymes will provide a new workhorse in white biotechnology.